Analyzing a drug's pharmacokinetic interactions is essential for predicting risks associated with certain medications. This can be predicted through dedicated interaction studies, clinical case reports, and in vitro to in vivo extrapolation (IVIVE) which uses in vitro experimental data to predict effects in vivo. Pharmacodynamics is also an important factor in drug interactions. This involves knowing and understanding the mechanisms of actions and safety profiles of co administered drugs and their additive or antagonistic properties.