Some distinctive risk factors of suicide in middle aged women are correlated with depression. These include:

1. Hormone change, unstable mood and experience of physical pain during perimenopause and menopause 
2. Fear of losing shape and waning sexual appeal 
3. Grieving the loss of childbearing ability
4. Social inequality and work overload

Wake Forest University

There are many life events happening in middle-age that can be risk factors of suicide:

1. Unemployment and Job Loss: this adds burden on middle-aged adults due to financial pressure of supporting the family household. Also, unemployment is prevalent in middle-aged adults for company trying to recruit younger adults.

2. Marital Status and Divorce: loneliness and social disconnection are major risk factors for suicide. Also divorce is a major life event that contributed to enormous change and a failure of adjustment also contributes to increase risk of depression. 

3. Education: low educational attainment leads to higher vulnerability in suicide especially for adults.

Risk Factors for Suicide in Midlife Crisis

Feryad A. Hussain & Ray Cochrane (2002) Depression in South Asian women: Asian women's beliefs on causes and cures, Mental Health, Religion & Culture, 5:3, 285-311, DOI: 10.1080/13674670210130036

Depression in South-Asian Women

Some distinctive risk factors of suicide in midlife men includes:

1. Loss of Spouse
2. Years of heavy drinking/drug use
3. Personal experience with other suicides
4. Facing deliberating old age without psychological compensations
5. Waning physical health and energy

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