D614G is an amino acid in the S protein that was originally the most dominant variant of SARS-CoV-2. Located on the surface of the S protein protomer, D614G is responsible for forming a hydrogen bond with a neighboring promoter, which brings together the S1 subunit of a protomer with the S2 subunit of another protomer.

D614G

G614 is a variant of SARS-CoV-2 that is caused by a D614G amino acid change (A-G nucleotide change) in the S protein, which simultaneously also causes C-T mutations in three different areas of the spike

G614

- study on the first 37 fatal cases of SARS-CoV-2 in Wuhan, China revealed that V354F or V470A substitutions of the spike protein showed increased infectivity
- V354F and V470A are known to increase entry of pseudoviruses into cells expressing ACE2
- although this study is limited, it does suggest the challenge of creating novel therapeutics that target ACE2 and spike protein

V354/V470A

State University of New York at Stony Brook

University of Michigan - Ann Arbor

- mutation sites are distributed over the whole length of the SARS-CoV-2 spike protein sequence
- maximum mutation density was near the protease cleavage site
- D614G mutation is the only most common mutation in spike protein so far among various regions
- some mutations at the interface of the spike protein and ACE2 receptor could affect the efficacy of vaccines and other drugs


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