- study on the first 37 fatal cases of SARS-CoV-2 in Wuhan, China revealed that V354F or V470A substitutions of the spike protein showed increased infectivity
- V354F and V470A are known to increase entry of pseudoviruses into cells expressing ACE2
- although this study is limited, it does suggest the challenge of creating novel therapeutics that target ACE2 and spike protein

State University of New York at Stony Brook

S protein amino acid variants

Shu, C. J., Huang, X., Tang, H. H., Mo, D. D., Zhou, J. W., & Deng, C. (2021). Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2. Zoological Research, 42(2), 170-181.
DOI: 10.24272/j.issn.2095-8137.2020.301 

Mutations in spike protein and allele variations in
ACE2 impact targeted therapy strategies
against SARS-CoV-2

D614G is an amino acid in the S protein that was originally the most dominant variant of SARS-CoV-2. Located on the surface of the S protein protomer, D614G is responsible for forming a hydrogen bond with a neighboring promoter, which brings together the S1 subunit of a protomer with the S2 subunit of another protomer.

D614G

G614 is a variant of SARS-CoV-2 that is caused by a D614G amino acid change (A-G nucleotide change) in the S protein, which simultaneously also causes C-T mutations in three different areas of the spike

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