1Cademy - SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiency

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SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiency

This paper details a case study of an infant with X-linked severe combined immunodeficiency who was comorbid with COVID-19 while awaiting a stem cell transplant
The infant’s IgG antibody reactivities were tested with a microfluidic antigen array
Infant showed signs of mild bronchial wall thickening from CT scan and determined to have gotten COVID-19 from his father
Infant also contracted hepatitis and traditional treatment methods proved to be ineffective due to his immunological disease
Infant was then treated with COVID-19 convalescent plasma, patients condition improved after this therapy
Infant IgG levels were low, however the COVID-19 convalescent plasma therapy attempted to supplement these antibodies
Infant made recovery and had negative PCR testing after 87 days
Overall, infant did not manifest as many respiratory issues as most COVID-19 cases, but compromised immune system allowed for the hepatitis infection which worsened patient condition

Updated 2021-01-16

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