Method for adjusting significance levels in a linear regression analysis to account for multiple comparisons. Scheffé's method is a single-step multiple comparison procedure which applies to the set of estimates of all possible contrasts among the factor level means, not just the pairwise differences considered by the Tukey–Kramer method. It works on similar principles as the Working–Hotelling procedure for estimating mean responses in regression, which applies to the set of all possible factor levels.