Sentinel surveillance systems include longitudinal studies and seroprevalence surveys to determine the prevalence and severity of SARS-CoV-2 infections. These data collection methods can be used to determine optimal public health interventions and implement these community-wide changes. Existing records of pregnant patients and mother-baby linked longitudinal studies can facilitate data analysis and determine the solutions to imminent public health concerns. For example, population-based studies help to identify the risks of infection and compare susceptibility within different gestational and social parameters. Existing cohort studies used to observe the incidence of Zika virus can be modified to organize global data collection. The administration of new Covid-19 therapeutics and vaccines need to be constantly evaluated to determine its efficacy within this target population.