Tissue and fluid collection throughout prenatal and delivery care provide a convenient route of data collection. Specifically, routine maternal care can offer insights into SARS-CoV-2 infections within asymptomatic populations and will construct population-based approximations of viral seroprevalence. Currently, sentinel prenatal clinics are used to determine population-based estimates of HIV seroprevalence. Despite the disruption to prenatal care and wellcare visits, past infections, indicated by circulating antibodies, allow health professionals to understand the epidemiology of viral infections in pregnant women. Furthermore, fluid collection can occur directly after delivery and existing cohort studies provide easily accessible blood samples. Samples collected before the global pandemic, indicating the control population, would allow scientists to analyze various microbiomes, including viral pathogens, and detect potential background cross-reactivity.