Researchers aimed to investigate the effect of serum amyloid P (SAP) on single stranded RNA (ssRNA) induced lung damage and cytokine storm, especially since SARS-CoV-2 is a ssRNA virus. Mice were were exposed to oropharyngeal aspiration of ORN06, an ssRNA nucleotide that is GU-rich. Upon exposure, ORN06 induced lung damage and cytokine storm in the mice that closely resembled the lung damage and cytokine storm found in COVID-19 patients. Thus, the aspiration of ORN06 served as a simple model for COVID-19 patients with cytokine storm and lung damage. The mice were then given intraperitoneal injections of SAP. After injection with SAP, the mice experienced a reduction in lung inflammation, levels of inflammatory cells induced by ORN06 aspiration, alveolar wall thickness, levels of clot-like aggregates in the lungs, and levels of inflammatory cytokines. These results suggest that SAP may have therapeutic potential to treat COVID-19 and other diseases where lung damage and cytokine storm are developed.