Concept

Suicidal Ideation with Use of SSRIs

In the past, people have been warned of the possibility of increased suicidality with SSRIs (paroxetine) in the youth, as they found that most SSRIs (except fluoxetine) lacked proven effectiveness in that particular population of patients. In various trials, no statistically significant increase in suicidal thoughts or attempts was connected to placebo use. Many mechanisms were hypothesized to explain the potential phenomena. However, current research is insufficient in identifying whether antidepressants cause increased suicide risk or reduce it by treating depression.

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Updated 2026-05-02

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