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Suicidal Ideation with Use of SSRIs
In the past, people have been warned of the possibility of increased suicidality with SSRIs (paroxetine) in the youth, as they found that most SSRIs (except fluoxetine) lacked proven effectiveness in that particular population of patients. In various trials, no statistically significant increase in suicidal thoughts or attempts was connected to placebo use. Many mechanisms were hypothesized to explain the potential phenomena. However, current research is insufficient in identifying whether antidepressants cause increased suicide risk or reduce it by treating depression.
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References
Cheung, K., Aarts, N., Noordam, R., Van Blijderveen, J. C., Sturkenboom, M. C., Ruiter, R., Visser, L. E., & Stricker, B. H. (2015). Antidepressant use and the risk of suicide: A population-based cohort study. Journal of Affective Disorders, 174, 479-484. https://doi.org/10.1016/j.jad.2014.12.032
Cuffe, S. P. (n.d.). Do antidepressants increase the risk of suicide in children and adolescents? American Academy of Child and Adolescent Psychiatry. https://www.aacap.org/aacap/medical_students_and_residents/mentorship_matters/developmentor/Do_Antidepressants_Increase_the_Risk_of_Suicide_in_Children_and_Adolescents.aspx
Jick, H., Kaye, J. A., & Jick, S. S. (2004). Antidepressants and the risk of suicidal behaviors. JAMA, 292(3), 338–343. https://doi.org/10.1001/jama.292.3.338
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