This study investigates the effects of confinement during the COVID-19 pandemic on neuropsychiatric symptoms in patients with AD. AD neuropsychiatric symptoms include apathy, depression, anxiety, verbal and physical agitation, and hallucinations. In a cohort of 38 patients with AD, only 10 had neuropsychiatric changes during the confinement, between March 26, 2020 and May 9, 2020. For these 10 patients, the duration of confinement significantly correlated with both the distress experienced by their caregivers, as well as with the severity of their neuropsychiatric symptoms. These 10 patients had lower cognitive functioning in the 2 to 4 months prior to confinement, compared with the patients who did not demonstrate neuropsychiatric changes. AD patients with low cognitive function may be more prone to experience confusion and disorientation, which may have resulted in a greater incidence of neuropsychiatric symptoms during the confinement