LSD has been shown to help reduce alcoholism, as well as symptoms of depression, anxiety, and cluster headaches. Furthermore, evidence suggests LSD might have analgesic properties. 

Alma College

LSD effects the DMN in a remarkably
similar way to psilocybin. For instance,
LSD decreases within-network
connectivity (specifically the medialposterior DMN) and increases betweennetwork connections.


Modulation of DMN by LSD 

Gattuso, J. J., Perkins, D., Ruffell, S., Lawrence, A. J., Hoyer, D., Jacobson, L. H., Timmermann, C., Castle, D., Rossell, S. L., Downey, L. A., Pagni, B. A., Galvão-Coelho, N. L., Nutt, D., &amp; Sarris, J. (2022). Default mode network modulation by psychedelics: A systematic review. International Journal of Neuropsychopharmacology, 26(3), 155–188. https://doi.org/10.1093/ijnp/pyac074 

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