Default Mode Network modulation has been a consistent approach to understanding the effects and mechanisms of different psychedelic drugs. It is a current hypothesis that the relation of DMN modulation has a relation with the therapeutic effects of these drugs. Nonetheless, the mechanisms of this relation are still unclear.  

DMN modulation by use of psychedelics 

Several studies have related mechanisms within the DMN and neuropsychiatric disorders such as depression, PTSD, ADD, anxiety, schizophrenia, ADHD, and OCD. 

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The interacting brain regions that are engaged when we are not working on a task or focused on the external world. The same regions are active when we think about people (so our default thoughts are often about people).

Default mode network

Gattuso, J. J., Perkins, D., Ruffell, S., Lawrence, A. J., Hoyer, D., Jacobson, L. H., Timmermann, C., Castle, D., Rossell, S. L., Downey, L. A., Pagni, B. A., Galvão-Coelho, N. L., Nutt, D., &amp; Sarris, J. (2022). Default mode network modulation by psychedelics: A systematic review. International Journal of Neuropsychopharmacology, 26(3), 155–188. https://doi.org/10.1093/ijnp/pyac074 

Default Mode Network Modulation by Psychedelics: A
Systematic Review

Therapeutic implications of Default Mode Network

This network includes the mesial prefrontal cortex, the posterior cingulate cortex, the hippocampus, the precuneus, the inferior parietal lobe,  the temporal lobe, and the angular gyrus.

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