Topoisomerase IV adds double double stranded breaks to the newly synthesized DNA molecules. This is needed for prokaryotic DNA replication because the DNA is concatenated, or interlinked, after replication and must be separated. 

University of Wisconsin - Madison

Termination of replication occurs after the chromosome has been replicated. Uniquely in prokaryotes, topoisomerase IV is important in the termination of DNA replication. 
Key term in prokaryotic termination of replication:
- Topoisomerase IV

Termination of DNA Replication in Prokaryotes

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Microbiology covers the scope and sequence requirements for a single-semester microbiology course for non-majors. The book presents the core concepts of microbiology with a focus on applications for careers in allied health. The pedagogical features of the text make the material interesting and accessible while maintaining the career-application focus and scientific rigor inherent in the subject matter. Microbiology’s art program enhances students’ understanding of concepts through clear and effective illustrations, diagrams, and photographs.

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