In addition to milder case treatments, it requires circulatory support with fluid and vasopressors if clinically appropriate.

University of Michigan - Ann Arbor

- Respiratory Failure
- Shock
- Multiorgan Failure
- Greatly diminished level of consciousness (e.g., severe delirium, minimally conscious state, stupor, coma)
- Symptoms of severe COVID-19

Critical COVID-19 symptoms

Currently, there is no FDA-approved, consistent treatment plan for COVID-19. Treatment depends on the severity of disease, the patient's ability to self-isolate, and the presence of other risk factors. Individuals with mild to moderate cases of COVID-19 are able to treat themselves at home without hospitalization or clinical care. If an individual is hospitalized, treatments will focus on managing the most common and severe COVID-19 complications. 

Therapeutic Treatment of COVID-19

1. [MODULE 1: From Bench to Bedside, Section: 'GRAPHIC SUMMARY' (as of March 19, 2020)](https://docs.google.com/document/d/1gjUuqTLi7xqMVzgWeYAFulmaIiKzhYY89PVOJJVvlNo/edit#heading=h.gtn0tdsnrc43)
2. [MEDICAL STUDENT COVID-19 CURRICULUM](https://docs.google.com/document/d/13JfRRw1GEIKz4JCde8WcQBCHnu-7nn11P_z0dHov1eA/preview)


COVID-19 Graphical Summary

Treatment of Critical COVID-19

- Results from ARDS (acute respiratory distress syndrome)
- A top cause of COVID-19-related death
- Associated with an overactive immune response  which can lead to multi organ  failure

Respiratory Failure with COVID-19

1- 14 day home quarantine from the day of exposure

2- Droplet, eye, and contact precautions, where appropriate for providers

3- Return precautions

4- Supportive care: encourage eating and drinking, acetaminophen for comfort/fever

5- Many hospitals are avoiding or cautious ibuprofen due to theoretical risk, but there is no scientific evidence about a link between COVID-19 and NSAIDS (03.25.2020)

Treatment of Mild COVID-19

1. Airborne precautions for aerosolizing procedures
2. Supportive care: acetaminophen for comfort/fever
3. Respiratory support
4. ARDS treatment as needed
5. Treat comorbidities
   - Suspected sepsis: empiric antibiotics
   - Flu: oseltamivir
   - Asthma/COPD: bronchodilators MDI

Treatment of Moderate COVID-19

In addition to the milder situation treatments, it often requires hospitalization and advanced ventilatory support.

Treatment of Severe COVID-19

- Drugs
- Antiviral Treatments
- Drug-Drug Interactions of Proposed Treatments
- Traditional Treatments
- COVID-19 Pharmacokinetics

Interventions for COVID-19 treatment

As of today there are no antiviral therapies available for the treatment of COVID-19. However, there have been identified some potential druggable targets.

Learn Before

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