Vascular Hyperpemeability and Multi-organ failure in COVID-19
Cytokine storms increase risk of vascular hyperpermeability and multiorgan failure. When vascular permability is increased by pro inflammatory cytokines (and other factors), large amounts of fluid and blood cells enter the alveoli. This results in dyspnoea (difficulty of breathing) and even respiratory failure. When the high concentration of cytokines is not addressed, they can even lead to death.
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References
Making Sense of the Cytokine Storm: a conceptual framework for understanding, diagnosing, and treating hemophagocytic syndromes
COVID-19 Cytokine Storm: the interplay between inflammation and coagulation
Cytokine Release Syndrome in Severe COVID-19: Interleukin-6 Receptor antagonist Tocilizumab may be the key to reduce mortality
Tags
SARS-CoV-2 (COVID-19)
Biomedical Sciences
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