The study examined 12 children, mean age of 6 years old and ranging from 3-10 years old, that had been referred to a pediatric gastroenterologist with histories of abnormal development and gastrointestinal issues. 11 of the 12 subjects were male. These children underwent gastroenterological, neurological, and developmental assessments, including MRI, EEG lumbar punctures, and biopsy samplings. Findings indicated that the onset of behavioral symptoms was correlated with the administration time of the MMR vaccine in 8/12 children. All 12 children had intestinal abnormalities. Gastrointestinal disease and developmental regression seemed to correlate, with a common environmental trigger of the MMR vaccine.

• Problems with Wakefield (1998)’s Study Design and Conclusions