Wide European Cohort Study That Examines Expression Levels of COVID-19 Susceptible Biomarkers in Patients with Severe Asthma
A European U-BIOPRED (Unbiased BIOmarkers Predictive of REspiratory Disease outcomes) cohort study examined the mRNA expression level of ACE2, TMPRSS2, and Furin in the sputum, bronchial brush and bronchial biopsies of volunteer subjects. These three biomarkers are heavily involved in the pathogenesis of COVID-19, and it was hypothesized that these expression levels would correlate with asthma severity or other molecular phenotypes. These findings may help to explain why those with asthma and other respiratory diseases are more vulnerable to SARS-CoV-2 infection and symptoms of COVID-19.
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SARS-CoV-2 (COVID-19)
Biomedical Sciences
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