1Cademy - ACE 2 Receptor as a Pharmacological Target for Treating or Preventing COVID-19

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ACE 2 Receptor as a Pharmacological Target for Treating or Preventing COVID-19

Inhibition of the binding between the spike protein present on the surface of the virus and the ACE-2 receptor present in the membrane of the host cell. This interaction mediates the entry of the virus in the cell.
Because ACE 2 plays a central role in the pathogenesis of COVID-19, it is thought that it could be an efficient drug target that could either treat or prevent infection.

ACE2 normal role: -Critical to regulate processes such as pressure, wound healing, and inflammation.

-It helps modulate ANGII, a protein that increases blood pressure and inflammation, increasing damage to blood vessel lining and tissue.

COVID-19: -In response to COVID-19, ANGII has increased inflammation and the death of alveoli cells which are critical for bringing oxygen into the body...ACE2 prevents this.

-When COVID-19 virus binds to ACE2, it inhibits its action, thus increasing the effects of ANGII

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Updated 2020-10-31

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