Relation

Apical Constriction

  • Mechanism that precedes/ prepares for neural tube closure
  • Changes rectangular epithelial cells into wedge shaped-cells by forcing the cells to contract (via protein actomyosin)
  • Ultimately leads to bending of tissue, creating "hinge points" that are required for neural tube closure
  • While apical constriction is a required prerequisite for neural tube closure, questions remain about whether this process is needed during the act of neural tube closure itself
  • Knowing that many of the processes that drive cranial neural tube closure are unknown, apical constriction is being investigated for its possible role in this process

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Updated 2021-08-20

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