The translational value of the open field test has been validated in humans with agoraphobia. In this study, individuals with agoraphobia (AP), along with age-matched healthy controls (HC), were instructed to first walk freely around a soccer field. AP participants spent significantly more time closer to the edges of the soccer field than the HC group. Additionally, all participants were given a specific destination within the city, and their routes were remotely monitored. The GPS data shows that most AP participants avoided crossing the market square, which in this study is considered the open field. HC participants crossed the market square, as this provided the shortest route to the destination. This data provides evidence that thigmotaxis can be demonstrated in humans and is related to anxiety disorders such as agoraphobia.