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Relation

Cellular Mechanisms of REM-NREM Sleep Switching

Cellular circuits control the switch between REM and NREM sleep. Excitatory glutamatergic neurons inhibit REM sleep and promote NREM sleep; these neurons share a common developmental origin with neurons that promote wakefulness. Downstream, inhibitory GABAergic (γ-aminobutyric acid-releasing) neurons act to inhibit REM sleep.

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Updated 2026-07-09

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