Concerns have been raised about the potential use of GAN-based human image synthesis for sinister purposes, e.g., to produce fake, possibly incriminating, photographs and videos. GANs can be used to generate unique, realistic profile photos of people who do not exist, in order to automate creation of fake social media profiles.

In 2019 the state of California considered and passed on October 3, 2019 the bill AB-602, which bans the use of human image synthesis technologies to make fake pornography without the consent of the people depicted, and bill AB-730, which prohibits distribution of manipulated videos of a political candidate within 60 days of an election. Both bills were authored by Assembly member Marc Berman and signed by Governor Gavin Newsom. The laws will come into effect in 2020.

DARPA's Media Forensics program studies ways to counteract fake media, including fake media produced using GANs.