Three preparatory psychotherapy sessions followed by three monthly cycles. Each consists of one MDMA-AP session followed by three integrative psychotherapy sessions. The preparatory and integrative sessions lasted 90 minutes, whereas the MDMA-AP sessions lasted 8 hours. There was a dosage increase in which the first session 75 mg were administered, and 75 or 125 mg were administered in the second and third sessions. Doses were established according to a joint decision by the participant, the physician, and the therapist. A supplemental dose of 50% of the initial dose was offered 90 to 120 minutes after the initial dose.