Exclusion criteria: fertile women who do not use contraceptives, a history of primary psychotic disorder, type 1 bipolar disorder, or personality disorder. Evidence or a history of coronary artery disease or peripheral vascular disease, hepatic disease, hypertension, weight below 48 kg. A history of hyponatremia or hyperthermia, presents a serious suicide risk, presenting a serious risk of injuring others. Having used illegal drugs more than 10 times in the last ten years or at least once in the past six months. Requiring psychiatric medications during the study.