• The primary goal of study was to assess the relationship between obesity, type 2 diabetes, and hypertension with severe COVID-19, in Mexico.

• Data was collected from all over Mexico using the Mexican Institute of Epidemiological Diagnosis and Reference; 18,443 tested negative, 3,844 tested positive, and 1,306 were positive for other respiratory viruses.

• Positive cases were compared to negative cases and those who were positive for other respiratory illnesses.

• Patients who tested positive had a higher proportion of obesity (17.4%), diabetes (14.5%), and hypertension (18.9%).

• Patients with obesity had a 1.43-fold chance of developing severe COVID-19, patients with diabetes had a 1.87-fold chance of developing severe COVID-19, and patients with hypertension had a 1.77-fold chance of developing severe COVID‐19.

• Obesity, diabetes, and hypertension were all significantly related to severe COVID-19 development in comparison to patients without these preexisting conditions.