Discussion of the First COVID-19 Patient with Multiple Myeloma Successfully Treated with Tocilizumab in Wuhan, China
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The peak in IL-6 levels after the initial decrease does not suggest COVID-19 relapse; in fact, this occurrence can be attributed to the recovery of nomral T cells
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The patient did not exhibit typical symptoms of COVID-19 such as fever and cough but experienced chest tightness and shortness of breath; this suggests that typical symptoms of COVID-19 are not present in patients with coexisting comorbidities such as multiple myleoma (MM)
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The patient's condition slowly recovered after tocilzumub treatment, suggesting that tocilizumab is an effective treatment of COVID-19
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IL-6 signaling plays a key role in the pathogenesis of MM and thus small molecule inhibitors that target this are extremely effective at stopping MM cell growth; the investigators believe that tocilizumab might also prove to be a useful therapeutic for MM
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Overall, this study is the first to report that tocilizumab is an effective treatment for COVID-19 patients also diagnosed with MM
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SARS-CoV-2 (COVID-19)
Biomedical Sciences
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Discussion of the First COVID-19 Patient with Multiple Myeloma Successfully Treated with Tocilizumab in Wuhan, China
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Patient History of the First COVID-19 Patient with Multiple Myeloma Successfully Treated with Tocilizumab in Wuhan, China
Results of the first COVID-19 Patient with Multiple Myeloma (MM) Successfully Treated with Tocilizumab in Wuhan, China