Relation

Discussion of the First COVID-19 Patient with Multiple Myeloma Successfully Treated with Tocilizumab in Wuhan, China

  • The peak in IL-6 levels after the initial decrease does not suggest COVID-19 relapse; in fact, this occurrence can be attributed to the recovery of nomral T cells

  • The patient did not exhibit typical symptoms of COVID-19 such as fever and cough but experienced chest tightness and shortness of breath; this suggests that typical symptoms of COVID-19 are not present in patients with coexisting comorbidities such as multiple myleoma (MM)

  • The patient's condition slowly recovered after tocilzumub treatment, suggesting that tocilizumab is an effective treatment of COVID-19

  • IL-6 signaling plays a key role in the pathogenesis of MM and thus small molecule inhibitors that target this are extremely effective at stopping MM cell growth; the investigators believe that tocilizumab might also prove to be a useful therapeutic for MM

  • Overall, this study is the first to report that tocilizumab is an effective treatment for COVID-19 patients also diagnosed with MM

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Updated 2020-07-23

Tags

SARS-CoV-2 (COVID-19)

Biomedical Sciences