1Cademy - Discussion/Conclusion - alpha-ketoamides effectiveness as broad-spectrum inhibitors against SARS-CoV viruses

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Discussion/Conclusion - alpha-ketoamide's effectiveness as broad-spectrum inhibitors against SARS-CoV viruses

This study identified the key differences in the binding pocket of the main protease in the SARS-CoV viruses, the Human corona virus, and several enteroviruses.
11r and 11u were the two most promising broad spectrum inhibitors tested for the viruses.
11r was is the most promising in its effectiveness against human coronaviruses and the SARS-CoV because of the similarity between the human corona virus and the SARS-CoV virus, this could lead to promising results with further testing of this inhibitor.
11u is the most broad-spectrum against the viruses tested. It proved to be the most equipotent in all the viral proteases.
11s and 11n proved to be less promising because of their lower potencies in other viruses however it was very effective at binding to the human corona virus binding pocket.

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Updated 2021-04-06

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