Concept
Proposed alpha-ketoamide Inhibitor: 11n
The IC50 of this inhibitor was 1.08 μM which was much lower than 11a, and the EC50 was 0.6 μM which are both positive readings showing that this was a successful inhibitor. It provided much better results compared to 11a because of the isobutyl group in replacement of the butyl group which allowed it to interact with the ”lid” and the and sufficiently bind.
However, it had very high EC50 values in the SARS-CoV virus, leading to believe it might not be as promising as a broad-spectrum inhibitor and with the human coronavirus.
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Updated 2021-04-06
Tags
SARS-CoV-2 (COVID-19)
Biomedical Sciences