- use of existing drugs to mitigate COVID-19
- health behaviors related to COVID-19 drug treatment

Effective COVID-19 Drug Targets and Candidates

These are drugs or drug targets that are either ineffective in mitigating COVID-19 or a SARS-CoV-2 infection, or they exacerbate the conditions. 

- ACE inhibitors (ACE-Is)
- angiotensin receptor blockers (ARBs)
- nonsteroidal anti-inflammatory drugs (NSAIDs)

Ineffective COVID-19 Drug Targets and Candidates

There are existing drugs that could, in theory, based on their physiological roles, have a positive pharmacological effect on treating or preventing COVID-19.  These drugs may not have been tested yet, or they may have been proved to be ineffective.  

- ACE2 inhibitors
- serine protease inhibitors
- Mas receptor activators
- SARS-S and MERS-S inhibitors 
- soluble ACE2 receptors
- combination therapies
- N-acetylcysteine (NAC)
- antimicrobial peptides
- androgen receptors
- probiotics targeting the gut microbiota
- coronaviral protease inhibitors
- ACE inhibitors + Angiotensin Receptor Blockers (ARBs)
- JAK inhibitors
- Alpha-lipoic acid (ALA)
- Hydrogen Sulfide (H2S)

Theoretical COVID-19 Drug Targets and Candidates

- effective drug targets and candidates
- ineffective drug targets and candidates
- theoretical drug targets and candidates

Michigan State University

- Therapeutic treatment
- Prophylactic treatment 
- Drug targets and candidates
- Preventive Treatment

Focuses of Pharmacology in COVID-19

A substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support.

Drug

Currently, there is no FDA-approved, consistent treatment plan for COVID-19. Treatment depends on the severity of disease, the patient's ability to self-isolate, and the presence of other risk factors. Individuals with mild to moderate cases of COVID-19 are able to treat themselves at home without hospitalization or clinical care. If an individual is hospitalized, treatments will focus on managing the most common and severe COVID-19 complications. 

Therapeutic Treatment of COVID-19

Prophylactic treatment may be used to prevent COVID-19 infection, especially for high-risk individuals. 

Prophylactic Treatment of COVID-19

Drug Targets and Candidates of COVID-19

As we do not have a vaccine for the virus yet, preventive measures are very important and should be strictly followed. Some of the preventive measures are:
- wearing a face mask
- social distancing
- hand sanitisers
- hand washing
- surface sanitisers

Scientists are also researching on certain oral antiseptics that inactive the virus in the mouth, thereby preventing the spread of COVID-19. 


Learn Before

Related

Learn After