Endothelial dysfunction is a cardiac condition that is the precursor of atherosclerosis. It is controlled by the so called "cardiovascular risk factors", and when these risk factors are treated, this condition can be reversed. Endothelial dysfunction leads to:

• plaque buildup in vascular tissue
• thrombosis
• vasoconstriction
• inflammation
• oxidative stress
• vascular tissue remodeling

Endothelial dysfunction is a comorbidity of conditions that have been shown to aggravate a SARS-CoV-2, including obesity. It also causes phenomena that might mechanistically enhance COVID-19.