Findings opposed to use of Hydroxychloroquine (HCQ) as COVID-19 intervention
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Hazard ratio for in-hospital mortality amongst hospitalized patients in NYC were not significantly different for those given HCQ
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Odds of cardiac arrest were higher in hospitalized patients in NYC given HCQ
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Odds of abnormal ECG findings were higher in hospitalized patients in NYC given HCQ
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From multinational registry of patients hospitalized between 12/20/19 and 4/14/20, individuals treated with HCQ had a higher risk of in-hospital mortality compared to an untreated control group
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From multinational registry of patients hospitalized between 12/20/19 and 4/14/20, individuals treated with HCQ had a higher risk of clinically significant ventricular arrhythmia compared to an untreated control group
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Hydroxychloroquine did not substantially reduce symptom severity in patients with early or mild COVID-19.
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As of now no randomized clinical trials reported have shown a positive correlation to COVID-19 recovery through the use of hydroxychloroquine
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A small randomized trial in Shanghai, China by Chen J, Liu D, Liu L, et al. revealed that by day 7, a total of 86% of the patients in the HCQ-treated group and 93% of those in the control group had negative results on viral throat swabs
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Researchers who used a randomized, double-blind, placebo-controlled study found no significant difference between new illness and symptoms compatible with COVID-19 infection in the hydroxychloroquine sulfate and placebo groups (11.8% and 14.3%, respectively).
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A study including 176 hospitals in the UK showed no significant difference between COVID-19 patients who received hydroxychloroquine and those who received usual care alone.
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Tags
SARS-CoV-2 (COVID-19)
Biomedical Sciences