- HTR1B encodes a G-protein coupled receptor for serotonin.
- Ligand-binding activates second messengers that inhibit the activity of adenylyl cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain.
- Receptor protein may be involved in several neuropsychiatric disorders (e.g., OCD and Personality Disorder); therefore, it is often a target of antidepressant and other psychotherapeutic drugs.

University of Minnesota - Twin Cities

The increased likelihood or chance of developing a particular disease due to the presence of at least one gene mutation and/or a family history that indicates an increased risk of the disease.

Genetic Predisposition

GeneCards: The Human Gene Database. (n.d). HTR1B Gene (Protein Coding). https://www.genecards.org/cgi-bin/carddisp.pl?gene=HTR1B

HTR1B Gene (Protein Coding)

- BDNF encodes a member of the nerve growth factor family of proteins, otherwise known as brain-derived neurotrophic factor.
- Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain.
   - Influences the growth, maturation (differentiation), and maintenance of these cells. 
- May play a role in the regulation of the stress response and in the biology of mood disorders.

BDNF Gene

HTR1B Gene

Genetic and psychology References

DRD4 gene receptor and psychiatric disorders 

MAOA gene and psychiatric disorders

MAOA Gene and psychiatric disorders 

Based on the principles of how inherited factors influence health, evaluate the patient's conclusion. Is their belief that they will inevitably develop the condition correct? Justify your answer.

Assessing Health Risk

An individual learns that their identical twin has been diagnosed with a psychological disorder known to have a significant genetic predisposition. What is the most accurate conclusion this individual can draw about their own health?

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