Individuals without means of income during lockdowns in LMICs may be unable to retrieve food, which ultimately threatens adherence to HIV therapy. Additionally, individuals diagnosed with HIV/AIDS have been unable to procure antiretrovirals (ARVs) or attend medical appointments due to COVID-19 lockdowns. Yet, with the aforesaid consequences, as well as with breaks in the global supply chain for ARVs, a six-month disruption in HIV efforts could result in over 500,000 additional deaths from AIDS-related illnesses in Sub-Saharan Africa during 2020-2021. In high-burden settings, deaths attributable to HIV over 5 years could increase by up to 10%.