This leads to the subsequent formation of the MAVS signalosome comprising of TRAF3, TRAF6, TANK, and TRADD. Once the signalosome is formed, it is followed by the addition of a phosphate molecule to IRF3 (phosphorylation) and IRF3 is then transported into the nucleus by IKK and/or TBK1 and Necrosis factor kappa B is also activated to increase the release of cytokines that promote inflammation and type 1 Interferons.