The 9b accessory protein compromises PCBP2 and AIP4 (a ubiquitin ligase) which leads to the specific degradation of MAVS, TRAF3, and TRAF6 in the MAVS signalosome and this hinders and reduces the interferon release by host cells. Additionally, it was also observed that if the expression of PCPB2 and AIP4 was reduced, the effect of the ORF9b protein on the MAVS signalosome was reversed along with any other antiviral host response that was inhibited/reduced by ORF9b. While this gives important information regarding the effects of ORF9b on host cells and its role in the pathogenesis of the virus, this mainly details the role of ORF9b protein in SARS-CoV and hence, studies are required to determine the exact role of this protein in SARS-CoV2 and to analyze if there are any significant differences in its mechanism of action.