Concept

Mechanisms and Key Concepts to Understand Role of ORF3a in Apoptosis: Bid/t-Bid

The role of Bid is seen when the death receptor signaling pathway and mitochondrion-dependent apoptosis pathway overlap which begins with the activation/cleavage of Bid to t-Bid (truncated Bid) by caspase 9 and this leads to the release of Cytochrome C into the cytosol (which leads to caspase-9 activation).

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Updated 2020-08-18

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Biomedical Sciences