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Method of Determining Role of ORF3a of SARS-CoV2 in apoptosis
Mechanisms and Key Concepts to Understand Role of ORF3a in Apoptosis: Cytochrome C
Mechanisms and Key Concepts to Understand Role of ORF3a in Apoptosis: Bid/t-Bid
Mechanisms and Key Concepts to Understand Role of ORF3a in Apoptosis: Caspase-9
The Role of ORF3a protein in apoptosis of host cells: Other Molecules of Mitochondrion-dependent Apoptosis
Cytochrome C, t-Bid, and cleaved/activated caspase-9 were observed in cells with expressed ORF3a and that if an inhibitor was used that inhibited the function of either caspase-8 or caspase-9, there was a drastic reduction in apoptosis of cells with the ORF3a protein. This further cements the proposition that ORF3a plays a role in triggering the extrinsic apoptotic pathway as well as the mechanism that links the death receptor signaling and mitochondrion-dependent apoptosis.
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SARS-CoV-2 (COVID-19)
Biomedical Sciences
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The Role of ORF3a protein in apoptosis of host cells: Caspase-8 and Bcl-2
The Role of ORF3a protein in apoptosis of host cells: Other Molecules of Mitochondrion-dependent Apoptosis
The Role of ORF3a protein in apoptosis of host cells: Caspase-3
The Role of ORF3a protein in apoptosis of host cells: Other Molecules of Mitochondrion-dependent Apoptosis
The Role of ORF3a protein in apoptosis of host cells: Other Molecules of Mitochondrion-dependent Apoptosis
The Role of ORF3a protein in apoptosis of host cells: Other Molecules of Mitochondrion-dependent Apoptosis