1Cademy - The Role of ORF3a protein in apoptosis of host cells: Caspase-8 and Bcl-2

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Method of Determining Role of ORF3a of SARS-CoV2 in apoptosis
Mechanisms and Key Concepts to Understand Role of ORF3a in Apoptosis: Caspase-8
Mechanisms and Key Concepts to Understand Role of ORF3a in Apoptosis: Bcl-2

Concept

The Role of ORF3a protein in apoptosis of host cells: Caspase-8 and Bcl-2

Cleaved/activated caspase-8 was observed in the transfected cells but there was not expression of Bcl-2 indicated that ORF3a may have a pro-apoptotic function by affecting the extrinsic and not the intrinsic apoptotic pathway.

Updated 2020-08-18

Contributors are:

Arvind Natarajan

🏆 2

Who are from:

Ohio State University, Columbus

🏆 2

References

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

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Effect of Expression of ORF3a Protein of SARS-CoV2 on various Key Molecules Controlling Apoptosis (in HEK293T cells)

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