- Set of dopaminergic axons from the midbrain (specifically the substantia nigra) to the basal ganglia (striatum) 
- Has a crucial role in motor control 
- Significant loss of dopamine neurons in this pathway produces movement problems in Parkinson’s disease 

Rutgers University

- Monoamine transmitter
- Subtypes of dopamine (DA) include D1, D2, D3, D4, and D5 (numbered in the order of their discovery)
- Found in the midbrain and basal forebrain
- Two main dopaminergic neuron pathways include the mesostriatal
pathway and the mesolimbocortical pathway

Dopamine Neurotransmitter 

Breedlove, S. & Watson, N. (2017). Behavioral neuroscience, eighth edition. Oxford University Press.

Behavioral Neuroscience 8th Edition

Mesostriatal Dopamine Pathway

- Set of dopaminergic axons from the midbrain (VTA) to the limbic
system and cortex 
- Important in reward and reinforcement, especially via the dopamine 2 (D2) receptor - Abnormalities in this pathway are associated with some symptoms of schizophrenia

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