1Cademy - Methylation of NR3C1 Gene

Concept

Methylation of NR3C1 Gene

Alterations in NR3C1 methylation can occur early in life as consequences of stress exposure and can persist up to adulthood.
Higher NR3C1 methylation levels are also those with enhanced vulnerability to develop BPD.
- In adult rodent offspring of high compared to low maternal care, regions spanning the NR3C1 gene were differentially methylated and acetylated, highlighting that in the context of early life stress, alterations in gene-networks rather than in a single or few genes is involved.
- In humans, increased methylation levels within the NR3C1 promoter region was reported in subjects that had a history of early life adverse events.
- Significant association between NR3C1 methylation and self-injurious behavior/previous hospitalizations.
Increased methylation of CpG sites within the NR3C1 gene may contribute to BPD aetiopathogenesis.

Updated 2021-10-03

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