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Microbiome-Based Interventions in Anorexia Nervosa
Microbiome-based interventions and information may help to inform and supplement nutritional rehabilitation in anorexia nervosa treatment, so as to alleviate problems that occur in refeeding such as gastrointestinal issues, weight relapse, etc.. Existing refeeding regimens have not been found to restore normal levels of intestinal bacterial diversity despite weight restoration, possibly indicating dysbiosis as having a role in relapse following weight restoration. Fecal microbiota transplantation (FMT), in which microbiota from healthy donors are transplanted into patients to help re-establish microbiota diversity and improve nutritional restoration has recently been found to improve gut barrier function, microbiota diversity, and weight gain in anorexia nervosa patients. However, further evidence and research is needed to establish what constitutes a "healthy" microbiota profile and establish means of improving the likelihood of compatibility between donors and recipients. Probiotics are also being studied as adjuncts to standard treatment to non-invasively improve the gut microbiome and address certain comorbidities, as some orally-taken bacterial strains have been found to improve mood and gastrointestinal function.
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