miR-1246 Levels May Modulate ACE2 Expression Levels in the Small Airway Epithelium
miRNAs that are homologous to the 3' end of the ACE2 gene were assessed using the data set from the Wang research group to determine if ACE2 expression was modulated by smoking. miR-1246 is complementary to the 3′ untranslated region (3′UTR) of ACE2 mRNA. Predicted base pairing was assessed using TargetScanHuman 7.2 (http://www.targetscan.org/vert_72/). Affymetirx miRNA 2.0 arrays and TaqMan PCR reveal that miR-1246 expression is significantly decreased in smokers compared to nonsmokers (**P < 0.01 and ***P < 0.001). This miRNA may be involved in the mechanism that regulates ACE2 expression in the SAE.
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SARS-CoV-2 (COVID-19)
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