Effects of COVID-19 on the Lungs
A main feature of symptomatic COVID-19 disease is respiratory infection. Severe damage to the lungs during respiratory distress may cause pulmonary fibrosis, necessitating lung transplants. Lasting damages to the lungs may occur even in recovering patients with mild infections. SARS-CoV-2 targets the following cell types:
- Type I pneumocytes (AT1)
- Type II pneumocytes (AT2)
- alveolar macrophages
ACE2 expression is primarily seen in AT2 cells which have been shown to be involved in the reproduction and transmission of the virus. Viral targeting of alveolar macrophages is evidenced by N antigen expression.
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References
Time Course of Lung Changes at Chest CT during Recovery from Coronavirus Disease 2019 (COVID-19)
Lifelong Lung Damage: The Serious COVID-19 Complication That Can Hit People in Their 20s
Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19
Covid-19 infection and mortality: a physiologist’s perspective enlightening clinical features and plausible interventional strategies
Tags
SARS-CoV-2 (COVID-19)
Biomedical Sciences
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