- transgenic mice were administered a single 25 mg/kg dose of B38 after 12 hours of exposure to SARS-CoV-2
- used a phosphate- buffered saline as a control along with H4
- number of viral RNA copies decreased
- mice recovered at 3 days post-infection

State University of New York at Stony Brook

Type I NAbs bind to the flat surface on one side of the top saddle-like surface of RBD. There is competition between NAbs and hACE2 for RBD, which suggests that the NAb inhibits by blocking binding of hACE2
- NAb CB6
- NAb B38

Type I NAbs

Wu, Y., Wang, F., Shen, C., Peng, W., Li, D., Zhao, C., ... & Liu, L. (2020). A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2. Science, 368(6496), 1274-1278.

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