- transgenic mice were administered a single 25 mg/kg dose of B38 after 12 hours of exposure to SARS-CoV-2
- used a phosphate- buffered saline as a control along with H4
- number of viral RNA copies decreased
- mice recovered at 3 days post-infection

NAb B38

NAb CB6

Type I NAbs bind to the flat surface on one side of the top saddle-like surface of RBD. There is competition between NAbs and hACE2 for RBD, which suggests that the NAb inhibits by blocking binding of hACE2
- NAb CB6
- NAb B38

State University of New York at Stony Brook

- Type I: only binds to 'up' RBD
- Type II: only binds when at least 2 RBD are 'up'
- Type III: only binds to 'down' RBD
- Type IV: recognizes both 'up' and 'down' RBD
- the image below shows the antibody interactions with RBD to the left and antibodies to the right

Types of Neutralizing Antibodies Targeting SARS-CoV-2 RBD of S protein

Huang, Y., Sun, H., Yu, H., Li, S., Zheng, Q., & Xia, N. (2020). Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective. Antibody Therapeutics, 3(4), 285-299.
https://doi.org/10.1093/abt/tbaa028

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