State University of New York at Stony Brook

Type I NAbs bind to the flat surface on one side of the top saddle-like surface of RBD. There is competition between NAbs and hACE2 for RBD, which suggests that the NAb inhibits by blocking binding of hACE2
- NAb CB6
- NAb B38

Type I NAbs

- transgenic mice were administered a single 25 mg/kg dose of B38 after 12 hours of exposure to SARS-CoV-2
- used a phosphate- buffered saline as a control along with H4
- number of viral RNA copies decreased
- mice recovered at 3 days post-infection

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