SARS-CoV2 has been shown to trigger oxidative stress, an overaccumulation of free radicals.  This leads to an autoimmune response which results in inflammation.  Under normal conditions, nitric oxide synthase plays a role in reducing oxidative species, which would in turn reduce the amount of resulting inflammation.  In patients with SARS, inhalation of NO has improved arterial oxygenation.  Clinical trials are underway to understand the affects of inducible NO in patients with SARS CoV-2.  

Potential role of NO reducing COVID-19 triggered oxidative stress

NO causes a reduction in the palmitoylation of the spike protein, which is the covalent attachment of fatty acids  to cysteine. This affects the ability of the  coronavirus to fuse with ACE-2 receptors.  
NO also might cause a a reduction in RNA viral replication in its early stages of replication.  

NO as potential antiviral agent against COVID-19

- Potential role of NO reducing COVID-19 triggered oxidative stress
- NO as potential antiviral agent against COVID-19

Bowdoin College

No is naturally produced by the body and its functions include acting like a hormone in controlling various organs. Experts at Uppsala University have found that NO is the only substance seen so far to have a direct effect on the virus. It helps to reduce inflammation thereby decreasing the severity of the infection. 

NO (Nitric oxide) might be a possible treatment of COVID-19

Mir, M, J., Maurya, R. C. (2020) Nitric oxide as a therapeutic option for Covid-19 treatment: a concise perspective.  New Journal of Chemistry.  https://doi.org/10.1039/D0NJ03823G 

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