1Cademy - Potential use of zinc and chloroquine in treating COVID-19

Concept

Potential use of zinc and chloroquine in treating COVID-19

Zn is a lewis acid, meaning it accepts electrons
Zn2+ is stable
Zn2+ is able to cause apoptosis
Zn activates the NF-kB pathway, which results in the formation of cytokines that cause inflammation
Zn inhibits the entry of the COVID-19 virus
10 uM Zn-sulfate and Zinc-acetate can cut down RNA replication by 50%
Chloroquine can be used to prevent functioning of ACE2 receptors (which then prevents inflammation)
Chloroquine, similar to zinc, prevents the virus from being replicated
When non-protonated, chloroquine is considered to be found in acidic organelles (located in golgi apparatus, lysosomes)
Chloroquine can transport zinc ions and increases the uptake of those ions through lysosomes
Zinc and chloroquine, when combined, results in death of malignant cells due to an increase in chloroquine cytotoxicity
Ovarian cancer was treated with chloroquine containing zinc chloride. Normal cells/ non malignant cells contained extremely low levels of Zinc without chloroquine
Zinc directly inhibits the replication of the COVID-19 virus