Prophase is the first phase of karyokinesis in eukaryotic mitosis. During this stage, chromosomes condense to become visible, spindle fibers emerge from the centrosomes, the nuclear envelope breaks down, and the nucleolus disappears.

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Karyokinesis is the initial stage of the mitotic phase during which the cell nucleus divides through a sequence of distinct phases: prophase, prometaphase, metaphase, anaphase, and telophase.

Karyokinesis

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Prophase

Prometaphase is the second phase of mitotic karyokinesis. During this stage, chromosomes continue to condense, kinetochores appear at the centromeres, mitotic spindle microtubules attach to these kinetochores, and centrosomes move toward opposite poles of the cell.

Prometaphase

Metaphase is the third phase of mitotic karyokinesis. During this stage, the mitotic spindle is fully developed, centrosomes are positioned at opposite poles of the cell, and chromosomes line up along the metaphase plate with each sister chromatid attached to a spindle fiber from opposite poles.

Metaphase

Anaphase is the fourth phase of mitotic karyokinesis. During this stage, the cohesin proteins binding sister chromatids break down, allowing the sister chromatids (now individual chromosomes) to move toward opposite cellular poles. Concurrently, non-kinetochore spindle fibers lengthen, causing the cell to elongate.

Anaphase

Telophase is the final phase of mitotic karyokinesis. During this stage, chromosomes arrive at the opposite poles of the cell and begin to decondense while the nuclear envelope reforms around them.

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